Here is an excerpt from The Revenge of the Sith novelization that I really like.
Order Sixty-Six is the climax of the Clone Wars.
Not the end--the Clone wars will end some few hours from now, when a coded signal, sent by Nute Gunray from the secret Separatist bunker on Mustafar, deactivates every combat droid in the galaxy at once--but the climax.
It's not a thrilling climax; it's not the culmination of an epic struggle. Just the opposite, in fact. The Clone Wars were never an epic struggle. They were never intended to be.
What is happening right now is why the Clone Wars were fought in the first place. It is their reason for existence. The Clone Wars have always been, in and of themselves, from their very inception, the revenge of the Sith.
They were irresistible bait. They took place on remote locations, on planets that belonged, primarily, to "somebody else". They were fought by expendable proxies. And they were constructed as a win-win situation.
The Clone Wars were the perfect Jedi trap.
By fighting at all, the Jedi lost.
With the Jedi Order overextended, spread thin across the galaxy, each Jedi is alone, surrounded only by whatever troops he, she, or it commands. War itself pours darkness into the Force, deepening the cloud that limits Jedi perception. And the clones have no malice, no hatred, not the slightest ill intent that might give warning. They are only following orders.
In this case, Order Sixty-Six.
Hold-out blasters appear in clone hands. ARC-170s drop back onto the tails of Jedi starfighters. AT-STs swivel their guns. Turrets on hovertanks swung silently.
Clones open fire, and Jedi die.
All across the galaxy. All at once.
Jedi die.